Jeuveau is a purified botulinum toxin type A injectable approved to temporarily improve moderate to severe frown lines (glabellar lines). It relaxes the muscles that pull the brows together, with results visible in days and lasting around three to four months.
Overview
Jeuveau (prabotulinumtoxinA-xvfs) is a neuromodulator made by Evolus and approved by the FDA in 2019 for the temporary improvement of moderate to severe glabellar lines, the vertical "11" lines between the eyebrows. It is the first neurotoxin in the US developed purely for aesthetic use, which is why it is sometimes nicknamed "Newtox." It uses a 900 kDa botulinum toxin type A complex structurally similar to Botox, so injection technique, dosing and results are comparable.
Jeuveau works by blocking the nerve signals that make the corrugator and procerus muscles contract. With those muscles relaxed, the skin above them stops creasing and existing lines soften. In clinical trials, about half of patients showed improvement by day two and roughly 68 to 70 percent reached a two-grade improvement by day 30. Results typically last three to four months, and most patients are treated about three times a year. Providers also use Jeuveau off-label on forehead lines, crow's feet and other expression lines in the same way they use Botox or Dysport.
TL;DR Summary
Jeuveau is an FDA-approved neuromodulator for frown lines that performs like Botox: onset in two to five days, full effect by two weeks, and results lasting three to four months. It is often priced slightly below Botox per unit. Outcomes depend on the injector’s anatomy knowledge and dosing.
Jeuveau is priced per unit or per treatment area. The FDA-approved dose for frown lines is 20 units across five injection points, so a glabellar treatment typically runs $200 to $350 depending on your provider’s per-unit rate and location.
Average cost (USD)
Cost Range (USD)
Jeuveau is cosmetic and not covered by insurance. Many practices price per unit; others price per treatment area.
Jeuveau temporarily blocks acetylcholine release at the nerve-muscle junction. The treated muscles stop contracting with full force, the overlying skin smooths, and the lines that repeated frowning carved in soften over the following two weeks.
Moderate to severe frown lines between the brows (on-label). Providers also treat forehead lines, crow’s feet, bunny lines and a lip flip off-label using the same approach as Botox.
About 10 to 15 minutes. The standard glabellar protocol is five injections of four units each, placed in the corrugator and procerus muscles.
Adults with dynamic frown lines. Not for people who are pregnant or breastfeeding, have a neuromuscular disorder such as myasthenia gravis, an active infection at the site, or a known allergy to botulinum toxin products.
None. You can return to work immediately. Avoid rubbing the area, lying flat or strenuous exercise for about four hours after treatment.
Jeuveau relaxes the muscles responsible for expression lines, so it is most effective on wrinkles created by movement rather than by sun damage or volume loss. Below are the concerns this treatment addresses, each explained on its concern page.
Dynamic wrinkles form where facial muscles repeatedly fold the skin. Jeuveau reduces that muscle activity so the skin stays smoother at rest and lines stop deepening with every expression.
The vertical "11" lines between the brows are Jeuveau's FDA-approved indication. Relaxing the corrugator and procerus muscles softens the lines and removes the tired or angry look they create.
Early fine lines around the brows and eyes respond well to low-dose neuromodulator treatment, which can prevent them from becoming etched-in static wrinkles over time.
Both are botulinum toxin type A products with a 900 kDa complex and the same mechanism of action. Jeuveau uses a different purification process and is approved only for frown lines, while Botox Cosmetic has broader approvals. In head-to-head trials their results were comparable.
Most patients see results for three to four months. Some report slightly longer duration, and a higher-dose formulation in phase 2 trials lasted up to six months, but that is not yet approved.
Improvement can start within two days. In trials about half of patients showed a visible change by day two, with full results by day 14 to 30.
The approved dose for frown lines is 20 units split across five injection sites. Forehead and crow’s feet treatments, done off-label, typically use 10 to 24 additional units each depending on muscle strength.
Yes. Dosing is one-to-one, so your provider can use the same unit count you had with Botox. Many patients switch for price without noticing a difference in results.
The needle is very fine and each injection feels like a quick pinch. Ice or numbing cream can be applied first if you are sensitive.
The following references provide clinical evidence and safety information on Jeuveau (prabotulinumtoxinA-xvfs):
Indication, clinical trial responder rates at day 2, 30 and 120, and full safety information.
Comparison of per-unit pricing, onset, duration and side-effect profiles.
Evolus phase 2 results on a higher-dose formulation lasting up to six months.
National count of neuromodulator injections performed in 2024.
All sources reviewed for clinical accuracy and relevance.
Cosmetic Injector
Isaac Waalen, PA-C is a nationally certified physician assistant with more than six years of experience in aesthetic medicine and a strong clinical foundation in human physiology.
Edina, MN
Licensed Master Aesthetician
Patricia “Patty” McIntosh is a Licensed Master Aesthetician at Spa Vitoria in Park City. She specializes in advanced laser treatments, skin rejuvenation, and non-surgical body contouring, with a personalized approach focused on client education, thoughtful treatment planning, and long-term skin health.
1441 Ute Blvd. Suite 140 Park City, UT
Licensed Master Aesthetician
Michelle Young is a Licensed Master Aesthetician at Spa Vitoria in Park City with more than 25 years of experience in medical aesthetics. She specializes in advanced skin and body treatments, including skin resurfacing, skin tightening, BBL, and non-surgical body contouring, with personalized treatment planning focused on long-term skin health.
1441 Ute Blvd. Suite 140 Park City, UT
Fellowship-Trained, Board-Eligible Plastic Surgeon
Dr. Justin Webb is a fellowship-trained plastic surgeon at Saltz Plastic Surgery, serving Salt Lake City and Park City. He specializes in breast surgery, tummy tuck, liposuction, and body contouring, with an approach centered on detailed surgical planning, clear communication, and natural-looking results.
5445 South Highland Drive Salt Lake City, UT
1441 Ute Blvd. Suite 140 Park City, UT
RN, BSN
Jaclyn McCreesh, RN, BSN, Aesthetic Nurse Injector at Bella Body Medical Spa in Yardley. Full-face balancing, injectable artistry, nearly two decades.
Yardley, PA
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