Back to treatments

Nanofat Grafting

Nanofat grafting is a regenerative treatment that uses refined fat to improve skin quality, texture, and tone by supporting collagen and cellular repair from within.

Find a Provider

Overview

What is Nanofat Grafting?

Nanofat grafting is an advanced form of fat transfer focused on skin regeneration rather than volume. Fat is gently harvested, processed into an ultra-refined liquid, and injected into areas where skin quality has declined.

Unlike traditional fat grafting, nanofat contains regenerative cells and growth factors but no intact fat cells. This makes it ideal for treating fine lines, crepey texture, under-eye darkness, and overall skin thinning.

By stimulating collagen production and improving microcirculation, nanofat grafting enhances skin health gradually. Results appear more natural and improve over time, making it a popular option for patients seeking subtle but meaningful rejuvenation.

Portrait of a smiling male medical professional wearing glasses and a white coat, standing outdoors in front of a tree.

Dr. Matthew Baker

M.D., Ph.D.

Cost of Nanofat Grafting

Pricing varies based on treatment area, extent of correction, and whether nanofat is combined with other procedures. Costs reflect surgical expertise, processing technique, and follow-up care.

85–95%

Success rates

$4,500

Average cost (USD)

100,000+

Procedures performed annually

Less than 2%

Complication rate

Average cost (USD)

$4,500

Cost Range (USD)

$3,000 – $8,000

Nanofat grafting is often performed alongside facelifts, blepharoplasty, or traditional fat transfer. Combining procedures may influence overall cost while improving long-term outcomes.

Pros and Cons of Getting Nanofat Grafting

Pros

  • Use your own tissue
  • Improves skin quality and texture
  • Supports collagen regeneration
  • Natural, gradual results
  • Minimal risk of allergic reaction
  • Can be combined with surgery

Cons

  • Not designed for volume restoration
  • Results take time to appear
  • Requires liposuction for fat harvest
  • Multiple areas may increase the cost
  • Not suitable for severe laxity alone
  • Results vary by skin biology

How it Works

Nanofat grafting works by delivering regenerative cells and growth factors into the skin to improve structure, elasticity, and tone over time.

What it Treats

Fine lines, crepey skin, under-eye darkness, thinning skin, and poor texture.

Procedure Time

Typically 60 to 90 minutes, depending on treatment areas.

Eligibility

Healthy adults with adequate donor fat and realistic expectations.

Recovery & Downtime

Mild swelling or bruising for several days. Most patients resume normal activity within a week.

What to Expect Before, During, and After Nanofat Grafting

Before Nanofat Grafting

A consultation evaluates skin quality, donor fat availability, and goals. You may be asked to stop certain medications and smoking prior to treatment.

During Nanofat Grafting

Fat is gently harvested, processed into nanofat, and injected into targeted areas using fine cannulas. Local or light sedation is commonly used.

After Nanofat Grafting

Temporary swelling or bruising is normal. Skin quality improves gradually over weeks to months as collagen remodeling occurs.

Potential Risks and Side Effects from Nanofat Grafting

Swelling and Bruising

Common at both donor and treatment sites and typically resolves within days.

Infection or inflammation

Rare when performed by licensed providers using sterile technique.

Uneven results

Skin response varies, and subtle asymmetries may occur during healing.

Frequently Asked Questions

Nanofat focuses on skin regeneration, not volume. The fat is processed so only regenerative components remain, making it ideal for texture and tone improvement rather than contouring.

Results are long-lasting because nanofat stimulates collagen production. Skin quality improvements may continue for several months and persist for years with proper care.

When performed by experienced providers, nanofat grafting has a strong safety profile. Using your own tissue reduces the risk of allergic reaction or rejection.

Early improvements may appear within weeks, but optimal results typically develop over three to six months as collagen remodeling occurs.

Yes. Nanofat is commonly combined with facelifts, eyelid surgery, or laser treatments to enhance overall skin quality and surgical outcomes.

Sources & Studies

The following references provide clinical evidence and safety information on Nanofat Grafting:

Foundational research introducing nanofat grafting, detailing its biological properties, processing techniques, and clinical applications in skin rejuvenation and regenerative aesthetics.

Seminal publication outlining the principles of structural fat grafting, including harvesting, processing, injection techniques, and long term outcomes for volume restoration.

Highly regarded medical journal featuring advanced surgical techniques, clinical studies, and outcomes research in plastic and reconstructive surgery.

Review article examining the role of adipose derived stem cells in skin regeneration, wound healing, and aesthetic applications, supporting the regenerative benefits of fat based treatments.

All sources reviewed for clinical accuracy and relevance.

Locate a Certified Clinic for Nanofat Grafting

Discover trusted, world-class clinics verified for safety, expertise, and patient experience.